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Not all next-gen sequencing technologies are created equal

The Next Generation Sequencing blog has a post on low coverage of A/T regions with Solexa sequencing. The post is in reference to a paper in Nature Methods on genome resequencing in C. elegans...

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This is the Future of Eukaryotic Genome Sequencing

As I have mentioned before, de novo sequencing of whole eukaryotic genomes may be a thing of the past (or, at least, these whole genome projects won’t be getting very much more common). Instead, I...

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Evidence that Men Think With Their Junk

Us dudes are always accused of thinking with our dicks. Perhaps it’s because the genes expressed in our brains are similar to those expressed in our ‘nads: Among the 17 tissues, the highest similarity...

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Watson’s Genome

Last year, Craig Venter became the first single person to have his genome sequence published (doi:10.1371/journal.pbio.0050254). That genome was sequenced using the old-school Sanger technique. It...

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Good-bye Frank!

Francis Collins, head of the National Human Genome Research Institute (NHGRI), will be stepping down from that position in August. Collins has overseen the sequencing of the human genome, the HapMap...

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Synteny — A Semantic Debate

There’s a post up at Pharyngula describing the concept of synteny in comparative genomics (Basics: Synteny). The definition given by PZ Myers will sound pretty familiar to those of you who have read...

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Adaptationist Junk

The human genome (like all mammalian genomes) is loaded with sequences that don’t perform any known function. And many of these sequences are junk. And it’s not just mammals — many animal genomes are...

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Genome Sequenced, Published via Press Release

Back in the day, you could sequence a genome and get a Nature paper out of it. Pretty soon, the sexiness of genome sequencing wore off, and it took a bit more to get into a vanity journal. You had to...

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Do people still use microarrays?

Larry Moran points to a couple of posts critical of microarrays (The Problem with Microarrays): Why microarray study conclusions are so often wrong Three reasons to distrust microarray results...

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The Implementation of Molecular Evolution for the Masses

A couple of years ago, there was talk in the bioblogosphere about getting the general public interested in bioinformatics and molecular evolution: Amateur bioinformatics? Lowering the Ivory Tower with...

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